Publications

2006
Rangel R, McKeller MR, Sims-Mourtada JC, Cain K, Kashi C, Melnikova V, Ananthaswamy HN, Blckburn MR, Cande C, Larochette N, Kroemer G, Singh KK and Martinez-Valldez H. PRELI protects mitochondria, prevents AIF nuclear translocation and opposes apoptosis, Submitted

Singh KK, Mitochondria damage checkpoint, aging, and cancer, Submitted

Singh KK, Desouki MM, Franklin RB, Feng P, Costello LC Mitochondrial aconitase in malignant and nonmalignant prostate, Submitted

Singh KK and Shroff M. Molecular Genetics of Arsenic Carcinogenesis. Arsenic 2006, Submitted

Goswami P and Singh KK Oxidative Stress and Multistage Carcinogenesis, In Oxidative stress, disease and cancer. Imperial College Press, London, In Press, 2006

Singh K.K. (Editor) Oxidative Stress, disease and cancer. Imperial College Press, London, In Press, 2006.

Rassmussen L and Singh, K.K. Oxidative Damage and Repair in the Mitochondrial Genome. In Oxidative damage to Nucleic Acid Mark, Editors Mark Evans & Marcus Cooke. Landes Biosciences, Houston, Texas, USA, In press, 2006

Zhang H, Chatterjee A and Singh KK Saccharomyces cerevisiae polymerase zeta functions in mitochondria. Genetics. 2006 Feb 1; [Epub ahead of print]

2005
Singh KK. Nanotechnology in cancer detection and treatment. Technol Cancer Res 4:583-584, 2005.

Gourley PL, Hendricks JK, McDonald AE, Copeland RG, Barrett KE, Gourley CR, Singh KK, Naviaux RK. Mitochondrial Correlation Microscopy and Nanolaser Spectroscopy - New Tools for Biophotonic Detection of Cancer in Single Cells. Technology in Cancer Research and Treatment. 4:585-592, 2005

Desouki MM, Kulawiec M, Bansal S, Das GM, Singh KK. Cross Talk Between Mitochondria and Superoxide Generating NADPH Oxidase in Breast and Ovarian Tumors. Cancer Biol Ther. 4:1367-73, 2005

Singh KK, Kulaweic M, Still I, Desouki MM, Geradts J, Matsui Sei-Ichi, Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis, Gene. 354:140-6, 2005

Ambrosone CB, Ahn J, Singh KK, Rezashiraz H, Furberg H, Sweeney C, and Trovato A Variability in genes related to oxidative stress and survival after treatment for breast cancer, Cancer Research, 65:1105-1111, 2005.

Franklin RB, Feng P, Milon B, Desouki MM, Singh KK, Kajdacsy-Balla A, Bagasra O, Costello LC. hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Molecular Cancer. 4:32, 2005

2004
Singh KK, Mitochondria damage checkpoint in apoptosis and genome stability, FEMS Yeast Research 5, 127-132, 2004

Napolitano, J. and Singh, KK, Mitochondrial dysfunction in cancer. Mitochondrion, 4:755-762, 2004

Mori N, Delsite R, Natarajan K, Bhujwalla ZM and Singh KK, Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline. Molecular Imaging, 3:319-323, 2004

Kachhap S and Singh K.K. Expression of uracil glycosylase inhibitor in mitochondria is not mutagenic. Molecular Cancer, 3:32-36, 2004.

Park SY, Bongkun C, Park YM, Singh KK, Lee M-S. Cellular aging of mitochondrial DNA-depleted cells. Biochemical Biophysical Research Communications 325:1399-1405, 2004

Singh K.K, Rasmussen A K, Rasmussen LJ Genome wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae. Ann NY Acad Sci 1011 284-298, 2004

Singh KK, Mitochondrial dysfunction is a common phenotype in aging and cancer. Annals of New York Academy of Sciences. 1019:260-264. 2004

Park SY, Chang I, Kang SW, Park S-H, Singh K.K. and Lee M-S, Resistance of mitochondrial DNA-depleted cells against cell death: Role of mitochondrial superoxide dismutase. J Biol Chem. 279:7512-7520, 2004

2003
Rasmussen AK, Chatterjee A, Rasmussen LR, and Singh K.K. Mitochondria-mediated-mutator phenotype in Saccharomyces cerevisiae. Nucleic Acid Research 31:3909-3917, 2003

Delsite RL, Rasmussen LJ, Rasmussen AK, Kalen A, Goswami PC and Singh KK. Mitochondrial impairment is accompanied by impaired DNA repair in the nucleus. Mutagenesis, 18: 497-503, 2003

Zhou S, Kachhap S and Singh KK. Mitochondrial impairment in p53 deficient human cancer cells. Mutagenesis, 18:287-292, 2003

Singh, K.K., Luccy, B.M., and Zullo, S.J. Mitochondria, Oxidative Stress and Mitochondrial Diseases. In: Oxidative Stress and Aging: Advances in Basic Science, Diagnostics, and Intervention. World Scientific Publishing Company, New York, NY, pp452-466., 2003

2002
Kim G, Sikder H and Singh KK. A colorimetric method identifies the vulnerability of mitochondria to oxidative damage. Mutagenesis, 17:375-381, 2002

Delsite RD, Kachhap S, Anbazhagan R, Gabrielson E, and Singh KK. Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells, Molecular Cancer 1: 6-15, 2002.

Napolitano, J. and Singh, K.K. Mitochondria as targets for detection and treatment of cancer. Expert Reviews in Molecular Medicine. 2002:1-19., 2002

2001
Parker, A., Gu, Y., Mahoney, W., Suk-Hee, L., Singh, K.K., and Lu, A. Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long-patch DNA base excision repair. J Biol Chem 276:5547-5555, 2001.

Singh, K.K., Sigala, B., Sikder, H.A., Kim, G., and Schwimmer, C. Inactivation of Saccharomyces cerevisiae OGG1 gene leads to increase frequency of mitochondrial deletions. Nucleic Acid Research 29:1381-1388, 2001

Jäger, A.C., Rasmussen, M., Bisgaard, H.C., Singh, K.K., Nielsen, F.C., and Rasmussen, L.J. HNPCC Mutations in the Human DNA Mismatch Repair Gene hMLH1 Influence Assembly of hMutL and hMLH1-hEXO1 Complexes. Oncogene 20:3590-3595, 2001.

Thorburn DR, Hans-Henrik DM, and Singh K.K. Pros and cons of mitochondrial manipulation in the human germ line. Mitochondrion 1:123-127, 2001

Chatterjee A, and Singh K.K Uracil-DNA glycosylase deficient yeast exhibits a mitochondrial mutator phenotype. Nucleic Acid Research 29:4935-4940, 2001

Naviaux R and Singh K.K. Manipulations of the mitochondrial germ line must be openly debated and followed up, Nature, 413:347, 2001

1996-2000
Rasmussen, L.J., Rasmussen, M., Bisgaard, H.C., Singh, K.K. The human cyclin B1 modulates the sensitivity of DNA mismatch repair deficient cancer cells to alkylating agents. Exp Cell Res 257:127-134, 2000.

Singh, K.K. The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant specific fashion. Free Rad Biol Med 29:1043-1050, 2000.

Singh, K.K. Mitochondrial me and the Mitochondrion journal. Mitochondrion 1:1-2, 2000.

Singh, K.K., Russell, J., Sigala, B., Zhang, Y., Williams, J.R., Keshav, K.F. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene 18:6641-6646, 1999.

Negelhus T, Huag, T., Singh, K.K., Keshav, K.F., Skorpen, F., Oteerlei, M., Bharati, S., Lindmo, T., Benichou, S., Benarous, R., and Krokan, H.E. Human Uracil-DNA gylcosylase interacts with the C-terminal part of the 34 KDa subunit of replication protein A. J Biol Chem. 272:6561-6566, 1997.

Singh, K.K. (Editor) Mitochondrial DNA mutations in Aging, Disease, and Cancer. Springer, New York, NY, 1998.

Kang D, Takeshig, K., Sekiguchi, M., and Singh, K.K. Mitochondrial DNA mutations in Aging, Disease, and Cancer: An Introduction. In Mitochondrial DNA Mutations in Aging, Disease, and Cancer, Springer, New York, NY, 1998.

Rassmussen L and Singh, K.K. Genetic integrity of mitochondrial genome. In Mitochondrial DNA mutations in Aging, Disease, and Cancer. Springer, New York, NY, 1998.

Singh, K.K and Hinemann, J. Yeast plasmids pp. 113-130. Methods in Molecular Biology: Expression and Detection of Recombinant genes. Vol.62. R. Tuan Ed, Humana Press Inc., Totowa, NJ, 1996.

1985-1995
Singh, K.K and Samson, L. Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes. Proc. Natl. Acad. Sci. 92:4907-4911, 1995.

Xiao, W., Singh, K.K.*, Chen, B., and Samson, L. A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG1 and MGT1) of Saccharomyces cerevisiae. Mol. Cell. Biol. 13:7213-7221, 1993.

Singh, K.K., Small, G.M., and Lewin, A.S. Alternative topogenic signals in peroxisomal citrate synthase of Saccharomyces cerevisiae. Mol. Cell. Biol. 12:5593-5599, 1992.

Singh, K.K and Norton, R.S. Metabolic changes induced during adaptation of Saccharomyces cerevisiae to a water stress. Arch Microbiol. 156:38-42, 1991.

Garret, J.M., Singh, K.K., Vonder Haar, R.A, and Emr, S.D. Mitochondrial protein import: isolation and characterization of Saccharomyces cerevisiae MFT1 gene. Mol. Gen. Genetics 225:483-491, 1991.

Mackenzie, K.F., Singh, K.K., and Brown, A.D. Water stress plating hypersensitivity of yeasts: Protective role of trehalose in Saccharomyces cerevisiae. J. Gen. Microbiol. 134:1661-1666, 1988.

Singh, K.K. and Vincents, W.S. Clumping characteristic and hydrophobic behavior of an isolated bacterial strain from sewage sludge. Appl Microbiol Biotech 25: 396-398, 1987.

Brown, A.D., Mackenzie, K.F., and Singh, K.K. Selected aspects of microbial osmoregulation. FEMS Micro Rev 39: 31-36, 1986.

Saxena, V.K., Tandon, S.M., and Singh, K.K. Anaerobic fermentation of cattle dung supplemented with water-hyacinth and green algae. Natl Acad Sci Lett 7:130-133, 1984.

Singh, K.K. and Verma, J. Methanogenesis with cheese industry waste water. Natl Acad Sci Lett 6: 275-277, 1983.

PATENTS
Singh, K.K. (2003) Colorimetric test for agents that induce mitochondrial dysfunction. US Patent number 6,479,251.